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Meta-Analysis the Effect of Pharmaceutical Care on Blood Glucose Level in Type 2 Diabetes Mellitus Patients

Muthia Syafira, Setyo Sri Rahardjo, Bhisma Murti

Abstract

Background: Pharmaceutical care is a patientoriented program carried out by pharmacists. In the management of type 2 diabetes mellitus (T2DM) several parameters have been determined as targets for the success of pharmaceutical care such as HbA1c and the level of patient compliance. This paper aims to evaluate the role of pharmaceutical care in improving clinical outcomes and compliance of patients with T2DM.
Subjects and Method: This study was conducted using a Systematic Review and Metaanalysis study design using PICO, population: Diabetes mellitus type 2 patients, Intervention: Obtaining pharmaceutical care. Comparison: Did not receive pharmaceutical care, Outcome: Hba1c. The articles used in this study came from 4 databases, namely Pubmed, ScienceDirect, ProQuest and Google scholar. Article keywords are Diabetes Mellitus, Type 2 OR T2DM OR Type 2 diabetes AND Pharmaceutical care OR Clinical pharmacy OR Community pharmacy OR Pharmacist* OR Pharmaceutical services OR Education OR Intervention OR Medication Management AND Knowledge OR adherence OR HbA1c OR glycemic control” Included articles in this study is a full paper article, RCT study design for 20112021.
Results: A total of 12 RCT studies with 1,746 T2DM patients in Asia (Jordan, Hong Kong, Northern Cyprus, Thailand, China, Malaysia and Indonesia), Americas (Brazil) and Europe (France and England). From the data processing, it was found that the provision of pharmaceutical care reduced HbA1c levels by 0.81 in patients with type 2 diabetes mellitus compared to those without pharmaceutical care. (SMD= 0.81; 95% CI= 1.11 to 0.52 p<0.0001).
Conclusion: The provision of pharmaceutical care can improve clinical outcomes in the form of decreasing HbA1c values.
Keywords: Pharmaceutical Care, Type 2 Diabetes Mellitus, HbA1c, Glycemic Control.

Correspondence: Muthia Syafira. Masters Program in Public Health Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email mutsyaf@student.ac.id. Mobile: +6285920660180.

Journal of Health Policy and Management, (2022), 07(02): 112-124
https://doi.org/10.26911/thejhpm.2022.07.02.03

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References

ADA (2021). ADA Standards of Medical Care in Diabetes 2021 Standards of Medical Care in Diabetes 2021.


Ali M, Schifano F, Robinson P, Phillips G, Doherty L, Melnick P, Laming L, et al. (2012). Impact of community pharmacy diabetes monitoring and education programme on diabetes management: a randomized controlled study. Br J Diabetes Vasc Dis. 29(9).e326e333. doi: 10.1111/j.14645491.2012.03725.x


Butt M, Mhd Ali A, Bakry MM, dan Mustafa N (2016). Impact of a pharmacist led diabetes mellitus intervention on HbA1c, medication adherence and quality of life: A randomised controlled study. Saudi Pharm J. 24(1): 4048. doi:10.1016/J.JSPS.2015.02.023


Cani CG, Da Silva GLL, Queiroz M, Nery M (2015). Improvement in medication adherence and selfmanagement of diabetes with a clinical pharmacy program: A randomized controlled trial in patients with type 2 diabetes undergoing insulin therapy at a teaching hospital. Clinics (Sao Paulo). 70(2):1026. https://doi.org/10.6061/clinics/2015(02)06.


Casten R, Rovner B, Chang AM, Hollander JE, Kelley M, Rising K et al (2020). A randomized clinical trial of a collaborative homebased diabetes intervention to reduce emergency department visits and hospitalizations in black individuals with diabetes Contemp. Clin. Trials 95. doi: 10.1016/J.CCT.2020.106069


Chan CW, Siu SC, Wong CKW, Lee VWY (2012). A pharmacist care program: Positive impact on cardiac risk in patients with type 2 diabetes. J Cardiovasc Pharmacol Ther. 17(1): 5764. doi: 10.1177/1074248410396216.


Choe HM, Mitrovich S, Dubay D, Hayward RA, Krein SL, Vijan S (2005). Proactive case management of highrisk patients with type 2 diabetes mellitus by a clinical pharmacist: a randomized controlled trial. Am J Manag Care. 11(4): 253260.


Chung WW, Chua SS, Lai PS, Morisky DE (2015). The Malaysian Medication Adherence Scale (MALMAS): Concurrent validity using a clinical measure among people with type 2 diabetes in Malaysia. PloS one: 10(4), e0124275.doi: 10.1371/journal.pone.0124275


DEPKES RI (2021). Pharmaceutical Care Untuk Penyakit Diabetes Mellitus Dep. Kesehat (Pharmaceutical Care for Diabetes Mellitus Dep. Health). RI 189


Eder S, Leierer J, Kerschbaum J, Rosivall L, Wiecek A, Mayer G, et al. (2019). Guidelines and clinical practice at the primary level of healthcare in patients with type 2 diabetes mellitus with and without kidney disease in five European countries Diabetes. Vasc Dis Res. 16(1): 4756. doi: 10.1177/1479164118795559.


Gautier JF, Boitard C, Michiels Y, Raymond G, Vergez G, Guedon G (2021). Impact of personalized text messages from pharmacists on medication adherence in type 2 diabetes in France: A realworld, randomized, comparative study Patient Educ. Couns. 104(9):22502258. doi: 10.1016/j.pec.2021.02.022


Barchi F, AbiNader MA, Winter SC, Obara LM, Mbogo D, Thomas BM, Ammerman B (2021). It is like medicine: Using sports to promote adult women's health in rural Kenya. IJERPH. 18(5): 2347. doi: 10.3390/ijerph18052347


Goruntla N, Mallela V, Nayakanti D (2019). Impact of pharmacistdirected counseling and message reminder services on medication adherence and clinical outcomes in type 2 diabetes mellitus. J Pharm Bioallied Sci. 11(1): 7782. doi: 10.4103/JPBS.JPBS_211_18.


IDF (2021). IDF Diabetes Atlas 10th edition 2021 In Diabetes Research and Clinical Practice. 102(2). doi:10.1016/j.diabres.2013.1.013
Ipingbemi AE, Erhun WO, Adisa R (2021). Pharmacistled intervention in treatment nonadherence and associated direct costs of management among ambulatory patients with type 2 diabetes in southwestern Nigeria. BMC Health Serv Res. 21(1). doi: 10.1186/S1291302106979Z.


Jarab AS, Almrayat R, Alqudah S, Thehairat E, Mukattash TL, Pinto S et al. (2014). Predictors of nonadherence to pharmacotherapy in patients with type 2 diabetes. Int J Clin Pharm. 36(4): 725733. 10.1007/s1109601499385


Jarab AS, Alqudah SG, Mukattash TL, Shattat G, AlQirim T, AlQirim T, et al (2012). Randomized controlled trial of clinical pharmacy management of patients with type 2 diabetes in an outpatient diabetes clinic in jordan J. Manag. Care Pharm. 18(7):

doi: 10.18553/jmcp.2012.18.7.516


Kazi AA, Blonde L (2021). Classification of diabetes mellitus In Clinics in Laboratory Medicine. 21(1). doi: 10.5005/jp/books/12855_84.


Korcegez E, Sancar M, pharmacy KD care and specialty, (2017). Effect of a pharmacistled program on improving outcomes in patients with type 2 diabetes mellitus from northern Cyprus: a randomized controlled trial Jmcp.Org 23(5). doi: 10.18553/jmcp.2017.23.5.573.


Levengood TW, Peng Y, Xiong KZ, Song Z, Elder R, Becenti A, et al. (2019). Teambased care to improve diabetes management: A community guide metaanalysis. Am J Prev Med. 57(1): e17e26. doi: 10.1016/J.AMEPRE.2019.02.005.


Mehuys E, Van Bortel L, De Bolle L, Van Tongelen I, Annemans L, Giri M et al. (2011). Effectiveness of a community pharmacist intervention in diabetes care: a randomized controlled trial 36(5): 602613. doi:10.1111/j.13652710.2010.01218.x.


Mourão AOM, Ferreira WR, Martins MAP, Reis AMM, Carrillo MRG, Ev LS et al (2013). Pharmaceutical care program for type 2 diabetes patients in Brazil: A randomised controlled trial. Int J Clin Pharm. 35(1): 7986. doi: 10.1007/s1109601297107.


Presley B, Groot W, Pavlova M, Services H, Health P (2019). Pharmacyled interventions to improve medication adherence among adults with diabetes: A systematic review and metaanalysis. Res Soc Adm Pharm. 15(9): 10571067. doi: 10.1016/j.sapharm.2018.09.021.


Shao H, Chen G, Zhu C, Chen Y, Liu Y, Jin H, et al(2017). Effect of pharmaceutical care on clinical outcomes of outpatients with type 2 diabetes mellitus Patient Prefer. Adherence 11: 897. doi: 10.2147/PPA.S92533


Sharp LK, Tilton JJ, Touchette DR, Xia Y, Mihailescu D, Gerber BS et al. (2018). Community Health Workers Supporting Clinical Pharmacists in Diabetes Management: A Randomized Controlled Trial Pharmacotherapy 38(1): 5868. doi:10.1002/phar.2058.


Wishah RA, AlKhawaldeh OA, Albsoul AM (2015). Impact of pharmaceutical care interventions on glycemic control and other healthrelated clinical outcomes in patients with type 2 diabetes: Randomized controlled trial. Diabetes Metab Syndr Clin Res Rev.

(4): 271276. doi: 10.1016/j.dsx.2014.09.001


Withidpanyawong U, Lerkiatbundit S, Saengcharoen W (2019). Familybased intervention by pharmacists for type 2 diabetes: A randomised controlled trial Patient Educ. Couns. 102(1): 8592. doi:10.1016/j.pec.2018.08.015.

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